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Celexa is an antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. You first start taking an MAO inhibitor before you can take Celexa. Celexa is a selective serotonin reuptake inhibitor used to treat depression associated with mood disorders. Citalopram is given as a single oral dose of 20 mg daily. Ssri medications affect the levels of serotonin in the brain called serotonin. Although Celexa is noted for its reduced instances of drug interactions, which could make the antidepressant a good choice for medically compromised individuals such as the elderly or those with co morbid illness. Celexa appears to be safe to use on a long-term basis and may cause less withdrawal when use is stopped. Although Celexa is noted for its reduced instances of drug interactions, you should always let your doctor know what other medications you are taking.