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Paxil should be taken once a day, either in the morning or evening, with or without food. Paxil should be taken once a day, either in the morning or evening, with or without food. Research has shown that depression and anxiety disorders usually require long-term treatment because of their chronic nature and the risk of relapse. Paroxetine is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors, may bring relief.
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