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The heart rate, systolic blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. Inderal contains the active ingredient Propranolol hydrochloride, which is already being administered, therapy should be initiated with conventional Inderal tablets following usual dosage recommendations. Propranolol from Inderal capsules is almost completely absorbed from the gastrointestinal tract and undergoes extensive presystemic elimination due to its high hepatic clearance. Treatment with Propranolol, as this combination can cause severely high blood pressure and heart failure. Propranolol may reduce the oxygen requirement of the heart and so decreases its demand for oxygen.