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Deltasone is used in so many conditions, only the most common or established uses are mentioned here. As corticosteroids reduce the normal response of the immune system plays an important role. Prednisone and Prednisolone are members of the glucocorticoid class of hormones. Prednisone is the most commonly-prescribed oral corticosteroid. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical.