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Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system. Ask your health care provider any questions you may have about how to use Fluconazole. Fluconazole is commonly used for prophylaxis in transplant patients. Fluconazole is one of the first-line drugs, particularly in treatment of infections. Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Fluconazole is commonly used for prophylaxis in transplant patients. Fluconazole will not treat a viral infection such as the common cold or flu. Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system. If you feel well.