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Metformin also increases your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar in your blood. Metformin decreases the amount of glucose in the blood. Metformin increases the sensitivity of muscle cells to insulin. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Take by mouth. Glucophage does not increase the body's production of insulin. Metformin decreases the amount of glucose in your blood.
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