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Synthroid is the number one prescribed treatment for thyroid disease, in conditions where the thyroid gland does not produce enough of thyroid hormone on its own, Synthroid is taken to replace the body's thyroid hormone. If you are taking Synthroid to make up for a lack of natural hormone, it is not effective as a weight-loss drug and should not be used as such. If you are taking Synthroid to make up for a lack of natural hormone, it is important to take it regularly at the same time every day. Thyroid supplements. Side effects produced by Synthroid include fatigue, increased appetite, weight loss, heat intolerance, and fever. Synthroid has profound effects on the body. Synthroid is the most commonly prescribed of all the thyroid supplements. For this reason the correct dose of Synthroid is difficult to find. Synthroid is a naturally occurring hormone produced by the thyroid glands also known as goiter.